Tissue health in transplant organs

The use of machine perfusion (MP) for the liver has grown exponentially in the past decade. During MP the liver is provided with a perfusion solution through the hepatic artery and portal vein, and the outflow is via the inferior vena cava. The perfusion is managed by continuously monitoring perfusate values, such as O2, CO2 and lactate concentrations,  Currently, we are measuring these values by measuring the perfusate going into the hepatic artery and portal vein, and coming out of the vena cava. We have no means to measure what is offered peripherally in the liver or which processes are taking place. In order to further understand and optimize the liver perfusion, there is an interest in understanding the differences between the central region of the liver compared to the outer regions of the liver during MP. 

Assignment

In this project the student will work on the development of an optical sensor for tissue vitality measurement. Some parameters have already been developed, so this should be expanded and intergrated. 

The student will work with researchers at Erasmus on measurements on living tissue.

Requirements

Some processing technology

Sensor development

Measurement

Contact

Last modified: 2026-03-24